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KMID : 0613820060160061060
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Journal of Life Science
2006 Volume.16 No. 6 p.1060 ~ p.1065
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Comparison of 99mTc-Tin colloid and 99mTc-DISIDA Hepatoscintigraphy in Miniature Pigs
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Sim Kyung-Mi
Kim Se-Eun
Bae Chun-Sik
Han Ho-Jae
Kang Sung-Soo
Park Soo-Hyun
Lee Won-Guk
Koong Sung-Soo
Lee Jae-Young
Choi Seok-Hwa
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Abstract
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Non-invasive evaluation of liver function in animal models remains a challenge. Hepatoscintigraphy provides information about changes in liver size and shape, and enables to understand general liver function. Futhermore it is readily used to diagnosis complications of liver transplantation like hepatitis, rejections and biliary complications. In this study, we investigated the usefulness of evaluating the liver function in miniature pigs with 99mTc-Tin colloid and 99mTc-DISIDA which are the most commonly used radiopharmaceuticals in human medicine. In result, 99mTc-Tin colloid was uptaked in lung, liver, gastric wall and kidney in miniature pigs. And 99mTc-DISIDA showed continuous uptake images of heart, lung, liver, gallbladder and duodenum, and it was similar to human’s. Therefore we could conclude 99mTc-Tin colloid would not be suitable for evaluating hepatic function because of it’s nonspecific affinity, however 99mTc-DISIDA scintigraphy would be an effective method for detecting hepatobiliary function in miniature pigs.
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KEYWORD
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Miniature pig, liver, scintigraphy, 99mTc-Tin colloid, 99mTc- 2, 6-diisopropyl iminodiacetic acid(DISIDA)
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